Ariad drug proves effective in curbing chronic leukemia in study












(Reuters) – An experimental leukemia drug from Ariad Pharmaceuticals Inc eliminated the cancer from the bone marrow of nearly half of patients with a chronic form of the disease who had stopped responding to other drugs, according to a 12-month follow-up of a pivotal drug trial.


The trial of the drug, ponatinib, which involved 444 patients, including 267 with chronic myeloid leukemia who had previously been treated with older drugs, also showed that 56 percent of chronic patients achieved the study’s goal of a “major response,” meaning the disease had nearly disappeared from the bone marrow.












Ariad earlier this year presented interim results from the trial, and U.S. Food and Drug Administration agreed in October to an expedited review. The agency is slated to decide by March 27 whether to approve ponatinib.


“We expect FDA approval sometime in the first quarter,” said Tim Clackson, Ariad’s chief scientific officer. He said the company is prepared to immediately launch sales of the drug. “We believe the overall trial data suggests activity in all forms of resistant disease.”


Ponatinib is designed to target an abnormal tyrosine kinase that is closely associated with chronic myeloid leukemia and Philadelphia chromosome positive acute lymphoblastic leukemia.


Ariad is also testing the drug in newly diagnosed CML patients. Final results from that trial are expected at the end of 2014, but an interim analysis will occur after half of the trial patients are enrolled, Clackson said.


Around 5,000 U.S. patients are diagnosed with CML each year, and about 2,500 patients will become resistant to their treatment, according to Ariad.


(Reporting By Deena Beasley; Editing by Leslie Adler)


Health News Headlines – Yahoo! News


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More Egypt protests called after Morsi concession


CAIRO (AP) — Egypt's liberal opposition called for more protests Sunday, seeking to keep up the momentum of its street campaign after the president made a partial concession overnight but refused its main demand he rescind a draft constitution going to a referendum on Dec. 15.


President Mohammed Morsi met one of the opposition's demands, annulling his Nov. 22 decrees that gave him near unrestricted powers. But he insisted on going ahead with the referendum on a constitution hurriedly adopted by his Islamist allies during an all-night session late last month.


The opposition National Salvation Front called on supporters to rally against the referendum. The size of Sunday's turnout, especially at Cairo's central Tahrir square and outside the presidential palace in the capital's Heliopolis district, will determine whether Morsi's concession chipped away some of the popular support for the opposition's cause.


The opposition said Morsi's rescinding of his decrees was an empty gesture since the decrees had already achieved their main aim of ensuring the adoption of the draft constitution. The edicts had barred the courts from dissolving the Constituent Assembly that passed the charter and further neutered the judiciary by making Morsi immune from its oversight.


Still, the lifting of the decrees could persuade many judges to drop their two-week strike to protest what their leaders called Morsi's assault on the judiciary. An end to their strike means they would oversee the Dec. 15 vote as is customary in Egypt.


If the referendum goes ahead, the opposition faces a new challenge — either to campaign for a "no" vote or to boycott the process altogether. A low turnout or the charter passing by a small margin of victory would cast doubts on the constitution's legitimacy.


It was the decrees that initially sparked the wave of protests against Morsi that has brought tens of thousands into the streets in past weeks. But the rushed passage of the constitution further inflamed those who feel Morsi and his Islamist allies, including the Muslim Brotherhood, are monopolizing power in Egypt and trying to force their agenda.


The draft charter was adopted amid a boycott by liberal and Christian members of the Constituent Assembly. The document would open the door to Egypt's most extensive implementation of Islamic law, enshrining a say for Muslim clerics in legislation, making civil rights subordinate to Shariah and broadly allowing the state to protect "ethics and morals." It fails to outlaw gender discrimination and mainly refers to women in relation to home and family.


Sunday's rallies would be the latest of a series by opponents and supporters of Morsi, who hails from the Muslim Brotherhood.


Both sides have drawn tens of thousands of people into the streets, sparking bouts of street battles that have left at least six people dead and hundreds wounded. Several offices of the Muslim Brotherhood also have been ransacked or torched in the unrest.


Morsi, who took office in June as Egypt's first freely elected president, rescinded the Nov. 22 decrees at the recommendation Saturday of a panel of 54 politicians and clerics who took part in a "national dialogue" the president called for to resolve the crisis. Most of the 54 were Islamists who support the president, since the opposition boycotted the dialogue.


In his overnight announcement, Morsi also declared that if the draft constitution is rejected by voters in the referendum, a nationwide election would be held to select the next Constituent Assembly.


The assembly that adopted the draft was created by parliament, which was dominated by the Brotherhood and other Islamists, and had an Islamist majority from the start. The lawmaking lower house of parliament was later disbanded by court order before Morsi's inauguration.


If the draft is approved in the referendum, elections would be held for a new lower house of parliament would be held within two months, Morsi decided.


The president has maintained all along that his Nov. 22 decrees were motivated by his desire to protect the country's state institutions and transition to democratic rule against a "conspiracy" hatched by figures of the ousted regime of Hosni Mubarak.


Morsi, whose claims have been repeated by leaders of his Brotherhood, has yet to divulge details of the alleged conspiracy.


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Barnes and Noble Nook HD+ is a Big Screen, Good Value Tablet












Barnes and Noble Nook-HD+


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[More from Mashable: 7 Stylish iPad Cases With Notepads]












The other night I handed the new Barnes and Noble HD+ to my son to see his reaction to one of the latest 9-inch tablets. He held it, played with the screen and said, “Which one is this?” I told him and he answered, “I can’t tell the difference anymore.” It’s true, with the sudden explosion of 7-, near-8-, 9- and 10-inch-plus tablets, it’s getting a little hard to tell which one is which — especially when many larger tablets look like their tinier siblings.


Barnes and Noble’s large-format (9-inch) HD-screen entry, the HD+, is a quite similar to the 7-inch Nook HD. However, with its somewhat sharper corners and far-reduced black-screen border, it’s also more similar in appearance to larger tablets such as the Amazon Kindle Fire HD 8.9. What sets the Nook apart visually is the trademark nook hole in the lower left-hand corner. It appears to serve no visible purpose, though you could hold the roughly 18-ounce tablet by that corner without too much stress on your hand. It is one of the lightest tablets on the market, although it’s thicker than the Google Nexus 10, Kindle Fire 8.9 and fourth-generation Apple iPad.


[More from Mashable: The 7 Best Tablets for Kids]


Nook HD+’s other distinctive feature is the physical “N” home button on the face of the device. It’s an attribute the Nook HD+ (and 7-inch Nook HD) share with the iPad. As I’ve said before, having that obvious “take me home” button on the front of the device is something I wish every tablet manufacturer would replicate.


Interface


Speaking of replicate, much of what is important and what you need to know about Barnes and Noble’s biggest tablet can be found in my review of the 7-inch Nook HD. The interfaces are exactly the same, so I won’t waste too much space recounting every bit of the Nook HD+ interface, which obscures any trace of Android 4.0, and is exquisitely usable.


The biggest difference between the Nook HD and the HD+ is screen resolution. The HD gets you 1440×900 pixels, while the HD+ offers 1920×1280, which is slightly more than the Kindle Fire HD 8.9’s 1920×1200. The latter two devices are almost the exact same size. By contrast, the competitors’ 7-inch devices are quite different because Amazon includes a front-facing camera, while Barnes and Noble does not include cameras on any of its tablets (if you plan on taking photos or video with your tablet, you can stop reading now). In the case of the Nook HD+, Barnes and Noble uses the space it saves on a camera for, it appears, 80 extra pixels of space. For the record, neither device beats the iPad’s 2048×1536 resolution.


Connectvity


Barnes and Noble also chose to leave out a cellular option from all of its tablets. Amazon, on the other hand, adds it in for the Kindle Fire HD 8.9 LTE. This is not as big of a deal as it seems since the world is filled with high-speed Wi-Fi. Still, if you plan to surf the web on your tablet while sitting on a train without another device to which to tether your HD+, look for products with the mobile broadband option, instead.


When it comes to connectivity, Amazon adds dual-band Wi-Fi to its HD Kindle Fires, while Barnes and Noble’s tablet remains single band. I’ve tested both devices in the most stressful situation -– streaming HD video -– and the difference is negligible.


Using It


Barnes and Noble Nook HD+’s profile-centric interface remains one of the best on the market. There is no learning curve; you simply drag your profile image to the unlock icon, and you have access to the large and uncluttered interface that features a carousel (which like the Kindle is a hodge-podge of disparate icons), your library and some recently used apps. Persistent menu items include the Library, Apps, Web, email and Shop. The screen also includes “your Nook Today,” which, along with the weather, is a place for Barnes and Noble to push shopping options based on your interests.


As you would expect, reading books and magazines is a pleasurable experience, especially on this larger screen. Magazines such as Esquire look great and, yes, Barnes and Noble still employs the animated page turn (though I don’t know for how much longer). Email and Web browsing are solid, and I prefer Barnes and Noble’s web solution to Amazon’s home-grown Silk browser, which crashed too often for my taste.


Social integration is fairly good on the Nook HD+. When I installed the Twitter client, it became one of my options for social sharing. That said, the app looks like it would be more at home on a small-screen smartphone than on the HD+’s 9-inch display. For Facebook, I opted for the web interface, which looks too tiny in portrait mode, but just right in landscape.


Movies and Music


I had no trouble buying, renting and streaming HD-quality movies such Arthur Christmas, and Netflix worked smoothly. Barnes and Noble, however, lacks its own streaming option. If you pay $ 75 a year for Amazon Prime, you get access to a vast library of streaming content. Both devices will let you play HD content on your big-screen TV, though they do it in slightly different ways.


Amazon’s Kindle Fire HD 8.9 comes complete with a mini-HDI-out port, and can accommodate a mini-to-standard HDMI cable (not included), so I could watch the HD content on my big-screen TV. The Nook HD+ lacks an HDMI port, but you can buy a $ 39 adapter (with an HDMI cable), which plugs into the tablet’s 30-pin port, to do the same thing.


I still prefer the Kindle HD platform for music since Amazon’s music services are more deeply integrated into the device and its cloud-based storage offering. On the Nook HD+ you have to start by finding the music service under Apps. If Barnes and Noble is serious about music, it should be on the main menu. Worse yet, if you open the Music app, it offers no instruction on how to fill your music library. You have to add tunes via your computer, by connecting to your PC with the proprietary cable or through the Micro SD slot where you can add more storage or place, say, an entire library of songs.


If you have a Rhapsody Account, you can use it to manage your music needs on the Nook HD+.


I almost never use my large tablet for music (that’s a job for my iPhone or iPod), so I don’t miss the rich music capabilities as much as some others likely would.


Apps and Performance


Like Amazon, Barnes and Noble curates its app library, which generally makes it safe and usable. The key apps, such as Netflix, Twitter, Dropbox, MobiSystems’ OfficeSuite, FlipBoard and Evernote, are all there.


I found some games on there, too, such as the Angry Birds Series and Cut the Rope. On the other hand, Barnes and Noble has very few action games. This may be because, while it’s running the same Texas Instruments Dual core 4470 CPU as the Kindle Fire HD 8.9, it doesn’t offer the same quadcore graphics processing power as Apple’s fourth-generation iPad.


Amazon actually includes the GPU-hungry Asphalt 7 in its app library, but the game does not look particularly good on the Kindle Fire HD 8.9. Obviously, Barnes and Noble chose not to take that risk.


Price


At $ 269 for the 16 GB model (I tested the $ 299 32 GB option), Barnes and Noble’s Nook HD+ is one of the most affordable large-screen tablets on the market — that price even includes the AC adapter. Amazon’s Kindle Fire HD 8.9 costs $ 299, but does not include the charger, and adds subsidizing sleep-screen ads. A 16 GB Wi-Fi-only fourth-generation iPad starts at $ 499.


Obviously, the iPad is more powerful, has a higher resolution and two cameras, while the Kindle, which also includes a camera, offers powerful Dolby stereo speakers (Nook HD+ has ones with decent volume) and unlimited cloud-based storage for your Amazon content. But if those features don’t matter to you, and you’re looking for an attractive, large-screen, light-weight, fun, effective and very affordable tablet from a company that knows a thing or two about good content, you can’t do better than the Nook HD+.


This story originally published on Mashable here.


Tech News Headlines – Yahoo! News


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Peru’s capital highly vulnerable to major quake












LIMA, Peru (AP) — The earthquake all but flattened colonial Lima, the shaking so violent that people tossed to the ground couldn’t get back up. Minutes later, a 50-foot (15-meter) wall of Pacific Ocean crashed into the adjacent port of Callao, killing all but 200 of its 5,000 inhabitants. Bodies washed ashore for weeks.


Plenty of earthquakes have shaken Peru‘s capital in the 266 years since that fateful night of Oct. 28, 1746, though none with anything near the violence.












The relatively long “seismic silence” means that Lima, set astride one of the most volatile ruptures in the Earth’s crust, is increasingly at risk of being hammered by a one-two, quake-tsunami punch as calamitous as what devastated Japan last year and traumatized Santiago, Chile, and its nearby coast a year earlier, seismologists say.


Yet this city of 9 million people is sorely unprepared. Its acute vulnerability, from densely clustered, unstable housing to a dearth of first-responders, is unmatched regionally. Peru’s National Civil Defense Institute forecasts up to 50,000 dead, 686,000 injured and 200,000 homes destroyed if Lima is hit by a magnitude-8.0 quake.


“In South America, it is the most at risk,” said architect Jose Sato, director of the Center for Disaster Study and Prevention, or PREDES, a non-governmental group financed by the charity Oxfam that is working on reducing Lima’s quake vulnerability.


Lima is home to a third of Peru’s population, 70 percent of its industry, 85 percent of its financial sector, its entire central government and the bulk of international commerce.


“A quake similar to what happened in Santiago would break the country economically,” said Gabriel Prado, Lima’s top official for quake preparedness. That quake had a magnitude of 8.8.


Quakes are frequent in Peru, with about 170 felt by people annually, said Hernando Tavera, director of seismology at the country’s Geophysical Institute. A big one is due, and the chances of it striking increase daily, he said. The same collision of tectonic plates responsible for the most powerful quake ever recorded, a magnitude-9.5 quake that hit Chile in 1960, occurs just off Lima’s coast, where about 3 inches of oceanic crust slides annually beneath the continent.


A 7.5-magnitude quake in 1974 a day’s drive from Lima in the Cordillera Blanca range killed about 70,000 people as landslides buried villages. Seventy-eight people died in the capital. In 2007, a 7.9-magnitude quake struck even closer, killing 596 people in the south-central coastal city of Pisco.


A shallow, direct hit is the big danger.


More than two in five Lima residents live either in rickety structures on unstable, sandy soil and wetlands that amplify a quake’s destructive power or in hillside settlements that sprang up over a generation as people fled conflict and poverty in Peru’s interior. Thousands are built of colonial-era adobe.


Most quake-prone countries have rigorous building codes to resist seismic events. In Chile, if engineers and builders don’t adhere to them they can face prison. Not so in Peru.


“People are building with adobe just as they did in the 17th century,” said Carlos Zavala, director of Lima’s Japanese-Peruvian Center for Seismic Investigation and Disaster Mitigation.


Environmental and human-made perils compound the danger.


Situated in a coastal desert, Lima gets its water from a single river, the Rimac, which a landslide could easily block. That risk is compounded by a containment pond full of toxic heavy metals from an old mine that could rupture and contaminate the Rimac, said Agustin Gonzalez, a PREDES official advising Lima’s government.


Most of Lima’s food supply arrives via a two-lane highway that parallels the river, another potential chokepoint.


Lima’s airport and seaport, the key entry points for international aid, are also vulnerable. Both are in Callao, which seismologists expect to be scoured by a 20-foot (6-meter) tsunami if a big quake is centered offshore, the most likely scenario.


Mayor Susana Villaran’s administration is Lima’s first to organize a quake-response and disaster mitigation plan. A February 2011 law obliged Peru’s municipalities to do so. Yet Lima’s remains incipient.


“How are the injured going to be attended to? What is the ability of hospitals to respond? Of basic services? Water, energy, food reserves? I don’t think this is being addressed with enough responsibility,” said Tavera of the Geophysical Institute.


By necessity, most injured will be treated where they fall, but Peru’s police have no comprehensive first-aid training. Only Lima’s 4,000 firefighters, all volunteers, have such training, as does a 1,000-officer police emergency squadron.


But because the firefighters are volunteers, a quake’s timing could influence rescue efforts.


“If you go to a fire station at 10 in the morning there’s hardly anyone there,” said Gonzalez, who advocates a full-time professional force.


In the next two months, Lima will spend nearly $ 2 million on the three fire companies that cover downtown Lima, its first direct investment in firefighters in 25 years, Prado said. The national government is spending $ 18 million citywide for 50 new fire trucks and ambulances.


But where would the ambulances go?


A 1997 study by the Pan American Health Organization found that three of Lima’s principal public hospitals would likely collapse in a major quake, but nothing has been done to reinforce them.


And there are no free beds. One public hospital, Maria Auxiliadora, serves more than 1.2 million people in Lima’s south but has just 400 beds, and they are always full.


Contingency plans call for setting up mobile hospitals in tents in city parks. But Gonzalez said only about 10,000 injured could be treated.


Water is also a worry. The fire threat to Lima is severe — from refineries to densely-backed neighborhoods honeycombed with colonial-era wood and adobe. Lima’s firefighters often can’t get enough water pressure to douse a blaze.


“We should have places where we can store water not just to put out fires but also to distribute water to the population,” said Sato, former head of the disaster mitigation department at Peru’s National Engineering University.


The city’s lone water-and-sewer utility can barely provide water to one-tenth of Lima in the best of times.


Another big concern: Lima has no emergency operations center and the radio networks of the police, firefighters and the Health Ministry, which runs city hospitals, use different frequencies, hindering effective communication.


Nearly half of the city’s schools require a detailed evaluation to determine how to reinforce them against collapse, Sato said.


A recent media blitz, along with three nationwide quake-tsunami drills this year, helped raise consciousness. The city has spent more than $ 77 million for retention walls and concrete stairs to aid evacuation in hillside neighborhoods, Prado said, but much more is needed.


At the biggest risk, apart from tsunami-vulnerable Callao, are places like Nueva Rinconada.


A treeless moonscape in the southern hills, it is a haven for economic refugees who arrive daily from Peru’s countryside and cobble together precarious homes on lots they scored into steep hillsides with pickaxes.


Engineers who have surveyed Nueva Rinconada call its upper reaches a death trap. Most residents understand this but say they have nowhere else to go.


Water arrives in tanker trucks at $ 1 per 200 liters (52 gallons) but is unsafe to drink unless boiled. There is no sanitation; people dig their own latrines. There are no streetlamps, and visibility is erased at night as Lima’s bone-chilling fog settles into the hills.


Homes of wood, adobe and straw matting rest on piled-rock foundations that engineers say will crumble and rain down on people below in a major quake.


A recently built concrete retaining wall at the valley’s head lies a block beneath the thin-walled wood home of Hilarion Lopez, a 55-year-old janitor and community leader. It might keep his house from sliding downhill, but boulders resting on uphill slopes could shake loose and crush him and his neighbors.


“We’ve made holes and poured concrete around some of the more unstable boulders,” he says, squinting uphill in a strong late morning sun.


He’s not so worried if a quake strikes during daylight.


“But if I get caught at night? How do I see a rock?”


___


Associated Press writer Franklin Briceno contributed to this report.


___


Frank Bajak on Twitter: http://twitter.com/fbajak


Latin America News Headlines – Yahoo! News


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On the edge of the “cliff,” U.S. cities like Charleston












CHARLESTON, South Carolina (Reuters) – For 37 years straight, Joseph P. Riley Jr. has sat behind the mayor’s desk here, shaping this city and its budget.


On a recent afternoon, Riley, 69, reached for a draft copy of next year’s spending plan and wondered aloud about what might get cut should politicians in Washington fail to find an agreement this month, unleashing $ 600 billion worth of spending reductions and tax hikes next year.












Hiring new police officers for the city of 123,000 could be put on hold, Riley said. A new piece of equipment for the fire department would have to wait. Sanitation workers might be in trouble, too.


“The thought that they would allow the economic harm that would ensue if we went over the fiscal cliff is mind-boggling,” said Riley, a Democrat who was elected to his 10th term last year.


Charleston, a beautiful city steeped in history and awash in tourist dollars, would seem at first glance a world apart from the harm that could be caused by the combination of spending cuts and higher taxes. Economists predict its arrival could send the United States hurtling back into a recession.


At its edges, however, Charleston harbors the people who are most vulnerable to Washington’s intransigence, making the city an emblem of a country’s worry and of the powerlessness people feel in the face of Washington’s indecision.


The sting of automatic cuts would be felt acutely by those who work in the defense sector and the poor. They form two prominent groups in Charleston County who may share little but the knowledge that federal belt-tightening is less a nuisance than an existential threat.


In South Carolina, defense spending accounts for $ 15.7 billion in annual economic activity – more than one in 10 dollars spent in the state – and nearly 140,000 jobs.


The Charleston area alone, which includes a large Air Force base and a Navy facility, holds more than 66,000 defense jobs and nearly half of the state’s military economic activity, according to a report released last month by the South Carolina Department of Commerce.


While Charleston, like the rest of the state, has seen a boom in military spending over the last decade, the area has the state’s second-highest concentration of people living in poverty, according to 2010 U.S. census data. More than one in four children live in poverty in the surrounding county.


From the anticipated cuts to the military to the shrinking of the safety net, Charleston shows what’s at stake should the United States fall off the fiscal cliff.


‘DEVASTATION’


A fast-talking engineer originally from Detroit, Michigan, Rebecca Ufkes founded UEC Electronics with her husband in neighboring Hanahan 17 years ago. Walking past employees in blue lab coats assembling components for military vehicles and commercial products last week, Ufkes described the chilling effect the possibility of cuts have had on Charleston’s defense industry.


In September, Ufkes traveled to Washington as a part of a lobbying effort organized by the Aerospace Industry Association, hoping to impress politicians with the dangers facing her 200-person company and its competitors should the anticipated $ 500 billion in defense cuts, over 10 years, come to pass.


She came away encouraged by her state’s largely Republican representation in Washington but frustrated by other lawmakers.


“South Carolina is a very pro-business state,” she said. “They are very keen on economics. It’s just that we are only one of 50 states.”


Ufkes, 48, said she worries not only about the uncertainty that has left defense contractors unsure where to invest but the impending tax increases, which she said will put her company, active in the commercial marketplace as well, at a disadvantage against foreign rivals.


“Probably the solution is not going to be perfect for UEC,” she said, “but I don’t want it to be devastating. Compromise and devastation are not the same thing.”


With a mug declaring, “Failure is not an option,” sitting on her desk, Ufkes predicted that her company would make it, no matter how devastating the cuts are.


“If we don’t survive,” she said. “I don’t know who will.”


NO ‘GIFTS’


Five miles (eight km) from Ufkes’ cutting-edge electronics manufacturer is the struggling North Charleston neighborhood of Chicora-Cherokee, where Bill Stanfield and his wife, Evelyn Oliveira, arrived fresh out of Princeton Theological Seminary 10 years ago.


They founded Metanoia, a development organization focusing on bettering the community by securing housing loans, planting a garden, and running after-school and summer programs.


Through government services like AmeriCorps, the national volunteer group, and funds from sources like the U.S. Department of Housing and Urban Development, Stanfield said his group received nearly a fifth of its funding from the federal government last year.


With politicians facing immense pressure over limiting cuts to entitlements like the Medicare health insurance program for seniors and the Social Security retirement program, advocates for the poor say they expect painful reductions in spending on education and housing.


“I don’t know if our housing program would survive,” Stanfield, 39, said.


Cuts to education will hit South Carolina hard, where the schools have bled money over the last five years.


According to the left-leaning Center on Budget and Policy Priorities, South Carolina’s cuts to education have been the fifth largest in the country, slicing 18 percent off of per-student spending during that period.


The Obama administration, which Republicans consider a profligate spender, has felt like lean times in neighborhoods like Chicora-Cherokee, Stanfield said.


“You know Mitt Romney said that people voted for Obama because of gifts?” Stanfield said. “There’s this misconception that President Obama has been a gravy train of funding. There was more funding under President Bush of these organizations than under Obama.”


‘GAME OF CHICKEN’


Last month, Riley, the Charleston mayor, went to Washington with a group of fellow city leaders, Democrats and Republicans, to lobby the White House and Congress to save cities from drastic cuts.


Vice President Joseph Biden and Democratic leaders from the House of Representatives and Senate met with the mayors. House Speaker John Boehner and other Republican leaders in Congress declined their invitation, Riley said.


While Riley supports Obama’s proposal to increase taxes on income earned over $ 250,000, a sticking point in the negotiations, he and other mayors cautioned that ending the tax-free status of municipal bonds would strangle cities’ access to needed capital.


Riley returned to Charleston feeling like a deal, which could prevent the harshest blows from hitting his city, its residents and jobs, was in the offing. Now, he said, he is not so sure.


“It looks like it’s a game of chicken,” he said, “and there are signals that they are going to go through with it.”


(Reporting By Samuel P. Jacobs Editing by Fred Barbash and Eric Beech)


Health News Headlines – Yahoo! News


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Rolling Stones rock Brooklyn at anniversary gig












NEW YORK (AP) — It sure didn’t feel like a farewell.


The Rolling Stones — average age 68-plus, if you’re counting — were in rollicking form as they rocked the Barclays Center in Brooklyn for 2½ hours Saturday night, their first U.S. show on a mini-tour marking a mind-boggling 50 years as a rock band.












And although every time the Stones tour, the inevitable questions arise, — whether it’s “The Last Time,” to quote one of their songs — there was no sign that anything is ending anytime soon.


“People say, why do you keep doing this?” mused 69-year-old Mick Jagger, the band’s impossibly energetic frontman, before launching into “Brown Sugar.” ”Why do you keep touring, coming back? The answer is, you’re the reason we’re doing this. Thank you for buying our records and coming to our shows for the last 50 years.”


Jagger was in fine form, with strong vocals and his usual swagger — strutting, jogging, skipping and pumping his arms like a man half his age. And though he briefly donned a flamboyant feathered black cape for “Sympathy for the Devil” and later, some red-sequined tails, he was mostly content to prowl the stage in a tight black T-shirt and trousers.


The band’s guitarists, the brilliant Keith Richards and Ronnie Wood, alternated searing solos and occasionally ventured onto a stage extension that brought them closer to the crowd. The now-gray Richards, wearing a red bandana, exuded the easy familiarity of a favorite uncle: “While we wait for Ronnie,” he said at one point, “I’ll wish you happy holidays.” Watts, the dapper drummer in a simple black T-shirt, smiled frequently at his band mates.


The grizzled quartet was joined on “Gimme Shelter” by Mary J. Blige, who traded vocals with Jagger and earned a huge cheer at the end. Also visiting: the Texas blues guitarist Gary Clark Jr.


The sense of nostalgia was heightened by projections on a huge screen of footage of the early days, when the Stones looked like teenagers. At one point, Jagger reminisced about the first time the band played New York — in 1964.


A carton of milk cost only a quarter then, he said. And a ticket to the Rolling Stones? “I don’t want to go there,” he quipped. It was a reference to the sky-high prices at the current “50 and Counting” shows, where even the “cheap” seats cost a few hundred dollars and a prime seat cost in the $ 700 range or higher.


From the opening number, “Get Off Of My Cloud,” the band played a generous 23 songs, including two new ones — “Doom and Gloom” and “One More Shot” — but mostly old favorites. The rousing encore included “Jumping Jack Flash,” of course, but the final song was “Satisfaction.” And though the song speaks of not getting any, the consensus of the packed 18,000-seat arena was that it was a satisfying evening indeed.


“If you like the Stones, this was as good a show as you could have had,” said one fan, Robert Nehring, 58, of Westfield, N.J., who’d paid $ 500 for his seat. “It was worth it,” he said simply.


The Brooklyn show was a coup for the new Barclays Center — there are no Manhattan shows. It followed two rapturously received Stones shows in London late last month. The band also will play two shows in Newark, N.J., on Dec. 13 and 15.


And just before that, the Stones will join a veritable who’s who of British rock royalty and U.S. superstars at the blockbuster 12-12-12 Superstorm Sandy benefit concert at Madison Square Garden. Also scheduled to perform: Paul McCartney, the Who, Eric Clapton, Bruce Springsteen & The E Street Band, Alicia Keys, Kanye West, Eddie Vedder, Billy Joel, Roger Waters and Chris Martin.


In a flurry of anniversary activity, the band also released a hits compilation last month with two new songs, “Doom and Gloom” and “One More Shot,” and HBO premiered a new documentary on their formative years, “Crossfire Hurricane.”


The Stones formed in London in 1962 to play Chicago blues, led at the time by the late Brian Jones and pianist Ian Stewart, along with Jagger and Richards, who’d met on a train platform a year earlier. Bassist Bill Wyman and Watts were quick additions.


Wyman, who left the band in 1992, was a guest at the London shows last month, as was Mick Taylor, the celebrated former Stones guitarist who left in 1974 and replaced by Wood, the newest Stone and the youngster at 65.


The inevitable questions have been swirling about the next step for the Stones: another huge global tour, on the scale of their last one, “A Bigger Bang,” which earned more than $ 550 million between 2005 and 2007? Something a bit smaller? Or is this mini-tour, in the words of their new song, really “One Last Shot?”


The Stones won’t say. But in an interview last month, they made clear they felt the 50th anniversary was something to be marked.


“I thought it would be kind of churlish not to do something,” Jagger told The Associated Press. “Otherwise, the BBC would have done a rather dull film about the Rolling Stones.”


There certainly was nothing dull about the band’s performance on Saturday, a show that brought together many middle-aged fans, to be sure, but also some of their children, who seemed to be enjoying the classic Stones brand of blues-tinged rock as much as their parents.


Yes, a Stone’s average age might be a bit higher than that of the average Supreme Court justice. (To be fair, the newest justices bring the average down). But to watch these musicians play with vitality and vigor a half-century on is to believe that maybe they were right when they sang, “Time Is On My Side.” At least for a few more years.


__


Associated Press writer David Bauder contributed to this report.


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More Egypt protests called after Morsi concession


CAIRO (AP) — Egypt's liberal opposition has called for more protests on Sunday after the president made concessions overnight that fell short of their demands to rescind a draft constitution going to a referendum on Dec. 15.


Morsi met one of the opposition's demands overnight, rescinding his Nov. 22 decrees that gave him near unrestricted powers. But he insisted on going ahead with the referendum on a constitution adopted by his Islamist allies.


The opposition National Salvation Front called on supporters to rally Sunday against the referendum.


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Election underscores Ghana’s democratic reputation












ACCRA, Ghana (AP) — Voters in Ghana selected their next president Friday in a ballot expected to mark the sixth transparent election in this West African nation, known as a beacon of democracy in a tumultuous region.


Proud of their democratic heritage, residents of this balmy, seaside capital trudged to the polls more than four hours before the sun was even up, standing inches apart in queues that in some places stretched 1,000-people deep.












By afternoon, some voters were getting agitated, after hitches with the use of a new biometric system caused delays at numerous polling stations.


Each polling station had a single biometric machine, and if it failed to identify the voter’s fingerprint, or if it broke down, there was no backup. At one polling station where the machine had broken down, a local chief said he’d barely moved a few inches: “I’m 58 years old, and I’ve been standing in this queue all day,” Nana Owusu said. “It’s not good.”


Late Friday, when it became clear that large numbers of people had not been able to vote, the election commission announced it would extend voting by a second day. This nation of 25 million is, however, deeply attached to its tradition of democracy, and voters were urging each other to remain calm while they waited their turn to choose from one of eight presidential contenders, including President John Dramani Mahama and his main challenger, Nana Akufo-Addo. The election commission


“Elections remind us how young our democracy is, how fragile it is,” said author Martina Odonkor, 44. “I think elections are a time when we all lose our cockiness about being such a shining light of democracy in Africa, and we start to get a bit nervous that things could go back to how they used to be.”


Ghana was once a troubled nation that suffered five coups and decades of stagnation, before turning a corner in the 1990s. It is now a pacesetter for the continent’s efforts to become democratic. No other country in the region has had so many elections deemed free and fair, a reputation voters hold close to their hearts.


The incumbent Mahama, a former vice president, was catapulted into office in July after the unexpected death of former President John Atta Mills. Before becoming vice president in 2009, the 54-year-old served as a minister and a member of parliament. He’s also written an acclaimed biography, recalling Ghana’s troubled past, called “My First Coup d’Etat.”


Akufo-Addo is a former foreign minister and the son of one of Ghana’s previous presidents. In 2008, Akufo-Addo lost the last presidential election to Mills by less than 1 percent during a runoff vote. Both candidates are trying to make the case that they will use the nation’s oil riches to help the poor.


Besides being one of the few established democracies in the region, Ghana also has the fastest-growing economy. But a deep divide still exists between those benefiting from the country’s oil, cocoa and mineral wealth and those left behind financially.


A group of men who had just voted gathered at a small bar a block away from a polling station in the middle class neighborhood of South Labadi. Danny Odoteye, 36, who runs the bar, said that the country’s economic progress is palpable and that the ruling party, and its candidate, are responsible for ushering in a period of growth.


“I voted for John Mahama,” he said. “Ghana is a prosperous country. Everything is moving smoothly.”


Administrator Victor Nortey, sitting on a plastic chair across from him, disagreed, saying the country’s newfound oil wealth should have resulted in more change.


“I voted for Nana Akufo-Addo,” He said. “Now we have oil. What is Mahama doing with the oil money?” Nortey said. “We can use that money to build schools.”


In an interview on the eve of the vote, Akufo-Addo told The Associated Press that the first thing he will do if elected is begin working on providing free high school education for all. “It’s a matter of great concern to me,” he said, adding that he plans to use the oil wealth to educate the population, industrialize the economy and create better jobs for Ghanaians.


Policy-oriented and intellectual, Akufo-Addo is favored by the young and urbanized voters. He was educated in England and comes from a privileged family. The ruling party has depicted him as elitist.


“The idea that merely because you are born into privilege that automatically means you are against the welfare of the ordinary people, that’s nonsense,” he said.


Ghana had one of the fastest growing economies in the world in 2011. Oil was discovered in 2007 and the country began producing it in December 2010.


Throughout the capital, new condominiums are rising up next to slums and luxury cars creep along narrow alleys lined with open sewers. A mall downtown features a Western-style cinema and is packed on weekends with middle class families. At the same time shantytowns are cropping up, packed with the urban poor.


Polls show that voters are almost evenly split over who can best deliver on the promise of development.


Kojo Mabwa said that he is voting for Akufo-Addo, because he is impressed by his promise of free education. He dismissed critics that say the project is too ambitious. “There is money,” he said. “(The ruling party) has done nothing for us. They are misusing our money.”


Paa Kwesi, a 30-year-old systems analyst, said he doesn’t think Akufo-Addo is making promises he can keep.


“He says he can do free education, but you have to crawl before you can walk. It’s not possible,” he said.


__


Associated Press writer Francis Kokutse contributed to this report from Accra, Ghana.


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Red Hat divulgará los resultados del tercer trimestre del año fiscal 2013 a través de un webcast












Red Hat Inc. (NYSE: RHT), proveedor líder mundial de soluciones de código abierto, analizará los resultados del tercer trimestre del año fiscal 2013 el jueves, 20 de diciembre de 2012, a partir de las 5:00 p. m., hora del Este.


Se puede acceder a un webcast en vivo en la página de Relaciones con los Inversores de Red Hat en http://investors.redhat.com y la reproducción se encontrará disponible a partir de aproximadamente dos horas luego de finalizados los eventos en vivo.












Acerca de Red Hat, Inc.


Red Hat es el proveedor líder mundial de soluciones de software de código abierto; utiliza un enfoque basado en la comunidad para tecnologías confiables y de alto rendimiento en la nube, Linux, middleware, almacenamiento y virtualización. Red Hat también ofrece servicios galardonados de consultoría asistencia y capacitación. Como centro de conectividad de una red global de empresas, socios y comunidades de código abierto, Red Hat ayuda a crear tecnologías relevantes e innovadoras que liberan recursos para el crecimiento y preparan a los clientes para el futuro de la tecnología de la información. Obtenga más información en: http://www.redhat.com.


Declaraciones a futuro


Ciertas declaraciones del presente comunicado de prensa pueden constituir “declaraciones a futuro” dentro del significado de la Ley de Reforma de Litigios Sobre Valores Privados (Private Securities Litigation Reform Act) de los EE. UU. de 1995. Las declaraciones a futuro ofrecen expectativas actuales de eventos futuros en base a determinados supuestos e incluyen cualquier declaración que no se relaciona directamente con cualquier hecho actual o histórico. Los resultados reales pueden diferir sustancialmente de los indicados por dichas declaraciones a futuro, como resultado de varios factores importantes, incluso: riesgos relacionados con retrasos o reducciones en el gasto en tecnología de la información; los efectos de la consolidación del sector; la capacidad de la Compañía de competir en forma eficaz; la incertidumbre y los resultados adversos en litigios y acuerdos relacionados; la integración de adquisiciones y la capacidad de comercializar en forma exitosa las tecnologías y productos adquiridos; la incapacidad de proteger adecuadamente la propiedad intelectual de la Compañía y el posible incumplimiento o violación de reclamaciones de licencia o relacionadas con la propiedad intelectual de terceros; la capacidad de entregar y estimular la demanda de nuevos productos e innovaciones tecnológicas en forma oportuna; los riesgos relacionados con la vulnerabilidad de la seguridad de datos y de información; la gestión ineficaz de, y control sobre las operaciones internacionales y el crecimiento de la Compañía; las fluctuaciones en las tasas de cambio; y cambios en el personal clave y una dependencia del mismo, así como otros factores presentes en nuestro más reciente Informe Trimestral en el formulario 10-Q (copias del cual se encuentran disponibles en el sitio Web de la Comisión de Bolsa y Valores en http://www.sec.gov), incluidos los que se encuentran en el título “Factores de riesgo” y “Análisis y Discusiones de la Gerencia sobre Condiciones Financieras y Resultados de Operaciones”. Además de estos factores, el desempeño futuro real, y los resultados pueden diferir sustancialmente debido a más factores generales que incluyen (entre otros) las condiciones generales del mercado y de la industria y las tasas de crecimiento, las condiciones económicas y políticas, los cambios en las políticas públicas y gubernamentales y el impacto de los desastres naturales como terremotos e inundaciones. Las declaraciones a futuro incluidas en este comunicado de prensa representan las opiniones de la Compañía a la fecha de este comunicado de prensa y estas ideas podrían cambiar. Sin embargo, si bien la Compañía puede elegir actualizar estas declaraciones a futuro en algún momento, la Compañía en forma específica renuncia a cualquier obligación de hacerlo. No debe confiar en estas declaraciones a futuro como si representaran las opiniones de la empresa a partir de cualquier fecha posterior de la fecha de este comunicado de prensa.


Red Hat y JBoss son marcas comerciales de Red Hat, Inc. registradas en los EE. UU. y en otros países. Linux® es la marca comercial registrada de Linus Torvalds en los EE. UU. y en otros países.


El texto original en el idioma fuente de este comunicado es la versión oficial autorizada. Las traducciones solo se suministran como adaptación y deben cotejarse con el texto en el idioma fuente, que es la única versión del texto que tendrá un efecto legal.


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Singer James Taylor suggested for lead role in “Lincoln”












WASHINGTON (Reuters) – Singer-songwriter James Taylor says he doesn’t see the resemblance, but he was pitched – without success – to play the role of U.S. President Abraham Lincoln in the new film.


Taylor told a packed audience at the National Press Club on Friday that Oscar-winning musician John Williams – who composed the soundtrack for “Lincoln” – had pushed for Taylor to play the lead role in Steven Spielberg‘s new film.












The role of Lincoln in the historical drama ultimately went to Oscar winner Daniel Day-Lewis.


“John wanted me to play that part. He actually stood up for me there and suggested me at one point,” said Taylor, 64, adding, “It was never going to happen.”


The “Fire and Rain” singer, who has no professional acting experience, said he was flattered that some people thought Day-Lewis’ portrayal of Lincoln reminded them of him. But he did not see much resemblance aside from the fact that they were “tall and somewhat skinny.”


“He doesn’t look like me to me, but I live in here, so I’m apt to notice the difference,” Taylor said.


British-born actor Day-Lewis, who already has two Oscars, is seen as a front runner to take home another golden statuette at the Academy Awards in February.


Taylor said he had no ambitions to go into acting after what he called “an interesting ride” of a performance career in which he essentially played himself.


“This is fine. I’ve spent my life being myself for a living,” said Taylor, a five-time Grammy Award winner.


“There are performers who develop and assume a character that they then play for the public. But I don’t know anyone who is as much themselves publicly for a living as I am,” he said.


Taylor and his third wife, Kim Taylor, campaigned actively for then-candidate Barack Obama in 2008 and again in 2012. The singer performed in Washington on Thursday evening at the 90th annual lighting of the National Christmas Tree, presided over this year by President Obama and his family.


(Reporting by Andrea Shalal-Esa; Editing by Jill Serjeant and Lisa Shumaker)


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