Britain launches genome database to improve patient care






LONDON (Reuters) – Up to 100,000 Britons suffering from cancer and rare diseases are to have their genetic codes fully sequenced and mapped as part of government efforts to boost drug development and improve treatment.


Britain will be the first country to introduce a database of genetic sequences into a mainstream health service, officials say, giving doctors a more advanced understanding of a patient’s illness and what drugs and other treatments they need.






It could significantly reduce the number of premature deaths from cancer within a generation, Prime Minister David Cameron‘s office said in a statement.


“By unlocking the power of DNA data, the NHS (National Health Service) will lead the global race for better tests, better drugs and above all better care,” Cameron said on Monday.


His government has set aside 100 million pounds ($ 160 million) for the project in the taxpayer-funded NHS over the next three to five years.


Harpal Kumar, chief executive of the charity Cancer Research UK, said the work would uncover new information from which doctors and scientists will learn about the biology of cancers and develop new ways to prevent, diagnose and treat them.


He said some targeted, or personalized, cancer treatments such as Novartis’ Gleevec, or imatinib – a drug for chronic myeloid leukemia – are already helping to treat patients more effectively.


Some critics of the project, known as the “UK genome plan”, have voiced concerns about how the data will be used and shared with third parties, including with commercial organizations such as drug companies.


Genewatch, a campaign group fighting for genetic science and technologies to be used in the public interest, has said anyone with access to the database could use the genetic codes to identify and track every individual on it and their relatives.


Cameron’s office said the genome sequencing would be entirely voluntary and patients would be able to opt out without affecting their NHS care. It said the data would be made anonymous before it is stored.


($ 1 = 0.6242 British pounds)


(Reporting by Kate Kelland; Editing by Stephen Powell and Tom Pfeiffer)


Medications/Drugs News Headlines – Yahoo! News


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Obama, Boehner meet face-to-face on 'fiscal cliff'



For the first time in more than three weeks, President Obama and House Speaker John Boehner met face-to-face Sunday at the White House to talk about avoiding the fiscal cliff.



White House Principal Deputy Press Secretary Josh Earnest would offer no details saying only, "The lines of communication remain open."



Erskine Bowles, the co-creator of a debt reducing plan, who was pessimistic a couple weeks ago, said he likes what he's hearing.



"Any time you have two guys in there tangoing, you have a chance to get it done," Bowles said on CBS's "Face the Nation."



The White House afternoon talks, conducted without cameras or any announcement until they were over, came as some Republicans were showing more flexibility about approving higher tax rates for the wealthy, one of the president's demands to keep the country from the so-called fiscal cliff -- a mixture of across-the-board tax increases and spending cuts that many economists say would send the country back into recession.



"Let's face it. He does have the upper hand on taxes. You have to pass something to keep it from happening," Sen. Bob Corker of Tennessee said on "FOX News Sunday."



This comes after the White House moderated one of its demands about tax rate increases for the wealthy.



The administration was demanding the rate return to its former level of 39.6 percent on income above $250,000. The so-called Bush tax cut set that rate at 35 percent. But Friday, Vice President Joe Biden signaled that rate could be negotiable, somewhere between the two.



"So will I accept a tax increase as a part of a deal to actually solve our problems? Yes," said Oklahoma Republican Tom Coburn on ABC's "This Week."



The problems the senator was referring to are the country's entitlement programs. And there was some progress on that front, too.



A leading Democrat said means testing for Medicare recipients could be a way to cut costs to the government health insurance program. Those who make more money would be required to pay more for Medicare.



"I do believe there should be means testing, and those of us with higher income and retirement should pay more. That could be part of the solution," Sen. Dick Durbin of Illinois said on NBC's "Meet the Press."



But Durbin said he would not favor raising the eligibility age from 65 years old to 67 years old, as many Republicans have suggested.



The White House and the speaker's office released the exact same statement about the negotiating session. Some will see that as a sign of progress, that neither side is talking about what was said behind closed doors.

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#OccupyCheerios: A Facebook Revolt






It wasn’t an obvious forum for an anti-GMO protest.


A YouTube video posted on Cheerio’s Facebook page depicts an elderly woman leaning over the highchair of her infant grandchild, cooing about family and the holidays, drawing a map with pieces of cereal representing relative’s far-flung houses. “But don’t you worry,” the grandmother says, pushing two Cheerios together, “we’ll always be together for Christmas.”






More than 1,200 users have commented on the vintage Cheerios commercial since it was posted last week, expressing outrage over the General Mills-owned brand’s use of genetically modified ingredients. Commenters have also been critical—like heavy-exclamation-points-use critical—of General Mills’ significant financial support of Prop. 37, California’s defeated GMO-labeling ballot initiative


Comments like “Can you please inform the public exactly why it is that General Mills spent $ 1.2 million to keep consumers in the dark about GMOs????” and “Nostalgic old commercials are no substitute for healthy ingredients. I won’t buy Cheerios until they are GMO-free” are a far cry from the stories of spending holidays with family—and perhaps a bit of Cheerios nostalgia—the post was surely intended to elicit.


The protest campaign was stoked by GMO Inside, an organization born of the failed Yes on 37 campaign. The group also called on people to comment-bomb a Cheerios app, which has since been removed from the company’s Facebook page. But beyond that, Cheerios’ response to the criticism has been . . . nothing. Anti-GMO comments are still piling up on the post, and no new material has been added to page in order to bury the video in the timeline.


Do 1,256 comments (and counting) cancel out $ 1.2 million of anti-Prop. 37 funding? Of course not. But just as the Occupy-style tactics being employed by protesters at Cooper Union and the Michigan State Capitol exhibit, showing up and voicing an opinion can be a powerful gesture, even if it’s not overpowering. 


Similar stories on TakePart


• Will GMOs Spell the End of Mexican Maize?


• Kellogg Recalls 2.8 Million Boxes of Cereal Due to Hazardous Metallic ‘Surprise’


• Anna Breslaw’s 600-Word Sprint: Nude Protests, Stripped Down



Willy Blackmore is the food editor at TakePart. He has also written about food, art, and agriculture for such publications as Los Angeles Magazine, The Awl, GOODLA Weekly, The New Inquiry, and BlackBook. Email Willy | TakePart.com


Social Media News Headlines – Yahoo! News


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McAfee wants to return to US, ‘normal life’






BACALAR, Mexico (AP) — Software company founder John McAfee said Sunday he wants to return to the United States and “settle down to whatever normal life” he can.


In a live-stream Internet broadcast from the Guatemalan detention center where he is fighting a government order that he be returned to Belize, the 67-year-old said “I simply would like to live comfortably day by day, fish, swim, enjoy my declining years.”






Police in neighboring Belize want to question McAfee in the fatal shooting of a U.S. expatriate who lived near his home on a Belizean island in November.


The creator of the McAfee antivirus program again denied involvement in the killing during the Sunday Internet video hook-up, during which he answered what he said were reporters’ questions.


His comments were sometimes contradictory. McAfee is an acknowledged practical joker who has dabbled in yoga, ultra-light aircraft and the production of herbal medications.


The British-born McAfee first said that returning to the United States “is my only hope now.” But he later added, “I would be happy to go to England, I have dual citizenship.”


He was emphatic that “I cannot ever return to Belize …. there is no hope for my life if I am ever returned to Belize.”


“If I am returned,” he said, “bad things will clearly happen to me.”


He descibed the health problems that had him briefly hospitalized earlier this week after Guatemalan authorities detained him for entering the country illegally. He apparently snuck in across a rural, unguarded spot along the border.


“I did not eat for two days, I drank very little liquids, and for the first time in many years I’ve been smoking almost non-stop,” he said. “I stood up, passed out hit my head on the wall, came to,” though he now said he was feeling better.


McAfee praised the role his 20-year-old Belizean girlfriend, Samantha Vanegas, played in his escape from Belize, where he claims he is being persecuted by corrupt politicians. Authorities in Belize deny that they are persecuting him and have questioned his mental state.


“Sam saved the day many times” during their escape, he said, and suggested he would take her with him to the United States if he is allowed to go there.


He confirmed that journalists from Vice magazine who accompanied him on his escape after weeks of hiding in Belize had unwittingly posted photos with embedded data that revealed his exact location.


“It was an error anyone could make,” he said, noting they were under a lot of pressure at the time.


McAfee has led an eccentric life since he sold his stake in the anti-virus software company named after him in the early 1990s and moved to Belize about three years ago to lower his taxes.


He told The New York Times in 2009 that he had lost all but $ 4 million of his $ 100 million fortune in the U.S. financial crisis. However, a story on the Gizmodo website quoted him as describing that claim as “not very accurate at all.”


McAfee’s Guatemalan attorney, Telesforo Guerra, says that he has filed three separate legal appeals in the hope that his client can stay in Guatemala, where his political asylum request was rejected.


Guerra said he filed an appeal for a judge to make sure McAfee’s physical integrity is protected, an appeal against the asylum denial and a petition with immigration officials to allow his client to stay in this Central American country indefinitely.


The appeals could take several days to resolve, Guerra said. He added that he could still use several other legal resources but wouldn’t give any other details.


Fredy Viana, a spokesman for the Immigration Department, said that before the agency looks into the request to allow McAfee to stay in Guatemala, a judge must first deal with the appeal asking that authorities make sure McAfee’s physical integrity is protected.


“We won’t look into (allowing him to stay) until the other appeal is resolved,” Viana said. “The law gives me 30 days to resolve the issue.”


McAfee went on the run last month after Belizean officials tried to question him about the killing of Gregory Viant Faull, who was shot to death in early November.


McAfee acknowledges that his dogs were bothersome and that Faull had complained about them, but denies killing Faull. Faull’s home was a couple of houses down from McAfee’s compound in Ambergris Caye, off Belize’s Caribbean coast.


Latin America News Headlines – Yahoo! News


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Iron may prevent behavioral issues in small babies






NEW YORK (Reuters Health) – Iron supplements may help boost brain development and ward off behavioral problems in babies who are born a bit on the small side, a new study from Sweden suggests.


Low birth-weight babies are more likely to end up iron deficient, researchers said. They need more of the nutrient for catch-up growth and haven’t stored as much as other babies if they’re also born premature.






For that reason, very early-term and very small babies are often put on iron – but less research has looked at babies born just shy of normal weight, to see if they are also at risk.


“I think this further solidifies the evidence that it’s a very good idea to give these (marginally low birth-weight) children iron supplements,” said Dr. Magnus Domellof, from Umea University, who worked on the study.


The research was led by his colleague, Dr. Staffan Berglund. Their team followed 285 infants born between 4 pounds, 7 ounces and 5 pounds, 8 ounces.


When the babies were six weeks old, the researchers randomly assigned them to get iron drops – either one or two milligrams per kilogram of body weight – or iron-free placebo drops each day until their six-month birthday.


Then at age three and a half, Domellof’s team brought the kids back for IQ tests and surveyed parents about their behavioral issues. The researchers compared kids in the iron- and placebo-drop study groups with another 95 children who were born at normal weight.


There were no IQ differences based on whether the smaller-than-average babies had been put on an iron regimen. All three low birth-weight groups had average scores between 104 and 105. (“Cognitive impairment” in this study was considered an IQ under 85.)


However, significantly more babies given placebo drops had behavioral problems, as reported by their parents. The issues included problems managing emotional reactions, anxiety and depression, as well as sleep and attention problems.


Almost 13 percent of the placebo-group babies scored above the cutoff for clinical behavior problems, versus about 3 percent of kids who’d taken iron drops and kids from the normal-weight comparison group.


That suggests iron deficiency in infancy may be a direct cause of behavioral problems later in childhood, the researchers wrote Monday in the journal Pediatrics.


They are continuing to monitor the same group of kids as they get older, to see if new cognitive or behavioral problems develop or old ones get better as the children head into grade school.


Domellof said he and his colleagues didn’t see any extra stomach problems in kids or delayed growth linked to the use of iron drops. Some research has suggested giving excessive iron to young kids who aren’t deficient may stunt their development.


But, “I would not be afraid of recommending this to all children (born) below 2,500 grams (5 pounds, 8 ounces) at this dose,” Domellof told Reuters Health.


“Here’s where an ounce of prevention is worth a pound of cure,” said Dr. Michael Georgieff, a child development researcher at the University of Minnesota in Minneapolis who had reviewed the study as part of Berglund’s dissertation committee.


He told Reuters Health that it’s important for all parents to know their baby’s iron requirements when they leave the hospital.


“The issue with these marginally low birth-weight infants is, people really haven’t paid a lot of attention to them, but the evidence is accumulating that they are at risk for behavioral problems and less than ideal cognitive function,” said Dr. Betsy Lozoff, who studies the effects of iron deficiency in infants at the University of Michigan in Ann Arbor.


For most babies in the United States, extra iron is recommended starting at four to six months, either through supplements if the mother is breastfeeding or through formula. Very small or premature babies typically have their iron monitored from birth.


But Lozoff, who wasn’t involved in the new research, said that in many places, there are no recommendations for how to treat babies who are just below a normal birth weight.


“This would suggest that it should just be a routine supplementation, and it can be at a low level of iron,” she told Reuters Health.


SOURCE: http://bit.ly/cxXOG Pediatrics, online December 10, 2012.


Health News Headlines – Yahoo! News


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Gabrielle Aplin tops UK charts with Power of Love






LONDON (Reuters) – English singer Gabrielle Aplin scored her first British number one on Sunday with a cover of the Frankie Goes To Hollywood hit “The Power of Love”, the Official Charts Company said.


Aplin climbed to number one from sixth place with the song, which first entered the charts in 1984 and is the theme for a Christmas television advert for British retailer John Lewis.






In the album charts, Olly Murs, a former runner-up in television’s X-Factor talent contest, held on to the top spot with his release “Right Place Right Time”, but saw his “Troublemaker” slip to third place in the singles ranks.


American singer Pink was the week’s highest climber in the singles top ten, jumping to eighth place from number 26 with “Try”.


(Reporting by Tim Castle; editing by Jason Webb)


Music News Headlines – Yahoo! News


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Obama, Boehner meet face-to-face on 'fiscal cliff'



For the first time in more than three weeks, President Obama and House Speaker John Boehner met face-to-face Sunday at the White House to talk about avoiding the fiscal cliff.



White House Principal Deputy Press Secretary Josh Earnest would offer no details saying only, "The lines of communication remain open."



Erskine Bowles, the co-creator of a debt reducing plan, who was pessimistic a couple weeks ago, said he likes what he's hearing.



"Any time you have two guys in there tangoing, you have a chance to get it done," Bowles said on CBS's "Face the Nation."



The White House afternoon talks, conducted without cameras or any announcement until they were over, came as some Republicans were showing more flexibility about approving higher tax rates for the wealthy, one of the president's demands to keep the country from the so-called fiscal cliff -- a mixture of across-the-board tax increases and spending cuts that many economists say would send the country back into recession.



"Let's face it. He does have the upper hand on taxes. You have to pass something to keep it from happening," Sen. Bob Corker of Tennessee said on "FOX News Sunday."



This comes after the White House moderated one of its demands about tax rate increases for the wealthy.



The administration was demanding the rate return to its former level of 39.6 percent on income above $250,000. The so-called Bush tax cut set that rate at 35 percent. But Friday, Vice President Joe Biden signaled that rate could be negotiable, somewhere between the two.



"So will I accept a tax increase as a part of a deal to actually solve our problems? Yes," said Oklahoma Republican Tom Coburn on ABC's "This Week."



The problems the senator was referring to are the country's entitlement programs. And there was some progress on that front, too.



A leading Democrat said means testing for Medicare recipients could be a way to cut costs to the government health insurance program. Those who make more money would be required to pay more for Medicare.



"I do believe there should be means testing, and those of us with higher income and retirement should pay more. That could be part of the solution," Sen. Dick Durbin of Illinois said on NBC's "Meet the Press."



But Durbin said he would not favor raising the eligibility age from 65 years old to 67 years old, as many Republicans have suggested.



The White House and the speaker's office released the exact same statement about the negotiating session. Some will see that as a sign of progress, that neither side is talking about what was said behind closed doors.

Also Read

Read More..

Peru’s capital highly vulnerable to major quake












LIMA, Peru (AP) — The earthquake all but flattened colonial Lima, the shaking so violent that people tossed to the ground couldn’t get back up. Minutes later, a 50-foot (15-meter) wall of Pacific Ocean crashed into the adjacent port of Callao, killing all but 200 of its 5,000 inhabitants. Bodies washed ashore for weeks.


Plenty of earthquakes have shaken Peru‘s capital in the 266 years since that fateful night of Oct. 28, 1746, though none with anything near the violence.












The relatively long “seismic silence” means that Lima, set astride one of the most volatile ruptures in the Earth’s crust, is increasingly at risk of being hammered by a one-two, quake-tsunami punch as calamitous as what devastated Japan last year and traumatized Santiago, Chile, and its nearby coast a year earlier, seismologists say.


Yet this city of 9 million people is sorely unprepared. Its acute vulnerability, from densely clustered, unstable housing to a dearth of first-responders, is unmatched regionally. Peru’s National Civil Defense Institute forecasts up to 50,000 dead, 686,000 injured and 200,000 homes destroyed if Lima is hit by a magnitude-8.0 quake.


“In South America, it is the most at risk,” said architect Jose Sato, director of the Center for Disaster Study and Prevention, or PREDES, a non-governmental group financed by the charity Oxfam that is working on reducing Lima’s quake vulnerability.


Lima is home to a third of Peru’s population, 70 percent of its industry, 85 percent of its financial sector, its entire central government and the bulk of international commerce.


“A quake similar to what happened in Santiago would break the country economically,” said Gabriel Prado, Lima’s top official for quake preparedness. That quake had a magnitude of 8.8.


Quakes are frequent in Peru, with about 170 felt by people annually, said Hernando Tavera, director of seismology at the country’s Geophysical Institute. A big one is due, and the chances of it striking increase daily, he said. The same collision of tectonic plates responsible for the most powerful quake ever recorded, a magnitude-9.5 quake that hit Chile in 1960, occurs just off Lima’s coast, where about 3 inches of oceanic crust slides annually beneath the continent.


A 7.5-magnitude quake in 1974 a day’s drive from Lima in the Cordillera Blanca range killed about 70,000 people as landslides buried villages. Seventy-eight people died in the capital. In 2007, a 7.9-magnitude quake struck even closer, killing 596 people in the south-central coastal city of Pisco.


A shallow, direct hit is the big danger.


More than two in five Lima residents live either in rickety structures on unstable, sandy soil and wetlands that amplify a quake’s destructive power or in hillside settlements that sprang up over a generation as people fled conflict and poverty in Peru’s interior. Thousands are built of colonial-era adobe.


Most quake-prone countries have rigorous building codes to resist seismic events. In Chile, if engineers and builders don’t adhere to them they can face prison. Not so in Peru.


“People are building with adobe just as they did in the 17th century,” said Carlos Zavala, director of Lima’s Japanese-Peruvian Center for Seismic Investigation and Disaster Mitigation.


Environmental and human-made perils compound the danger.


Situated in a coastal desert, Lima gets its water from a single river, the Rimac, which a landslide could easily block. That risk is compounded by a containment pond full of toxic heavy metals from an old mine that could rupture and contaminate the Rimac, said Agustin Gonzalez, a PREDES official advising Lima’s government.


Most of Lima’s food supply arrives via a two-lane highway that parallels the river, another potential chokepoint.


Lima’s airport and seaport, the key entry points for international aid, are also vulnerable. Both are in Callao, which seismologists expect to be scoured by a 20-foot (6-meter) tsunami if a big quake is centered offshore, the most likely scenario.


Mayor Susana Villaran’s administration is Lima’s first to organize a quake-response and disaster mitigation plan. A February 2011 law obliged Peru’s municipalities to do so. Yet Lima’s remains incipient.


“How are the injured going to be attended to? What is the ability of hospitals to respond? Of basic services? Water, energy, food reserves? I don’t think this is being addressed with enough responsibility,” said Tavera of the Geophysical Institute.


By necessity, most injured will be treated where they fall, but Peru’s police have no comprehensive first-aid training. Only Lima’s 4,000 firefighters, all volunteers, have such training, as does a 1,000-officer police emergency squadron.


But because the firefighters are volunteers, a quake’s timing could influence rescue efforts.


“If you go to a fire station at 10 in the morning there’s hardly anyone there,” said Gonzalez, who advocates a full-time professional force.


In the next two months, Lima will spend nearly $ 2 million on the three fire companies that cover downtown Lima, its first direct investment in firefighters in 25 years, Prado said. The national government is spending $ 18 million citywide for 50 new fire trucks and ambulances.


But where would the ambulances go?


A 1997 study by the Pan American Health Organization found that three of Lima’s principal public hospitals would likely collapse in a major quake, but nothing has been done to reinforce them.


And there are no free beds. One public hospital, Maria Auxiliadora, serves more than 1.2 million people in Lima’s south but has just 400 beds, and they are always full.


Contingency plans call for setting up mobile hospitals in tents in city parks. But Gonzalez said only about 10,000 injured could be treated.


Water is also a worry. The fire threat to Lima is severe — from refineries to densely-backed neighborhoods honeycombed with colonial-era wood and adobe. Lima’s firefighters often can’t get enough water pressure to douse a blaze.


“We should have places where we can store water not just to put out fires but also to distribute water to the population,” said Sato, former head of the disaster mitigation department at Peru’s National Engineering University.


The city’s lone water-and-sewer utility can barely provide water to one-tenth of Lima in the best of times.


Another big concern: Lima has no emergency operations center and the radio networks of the police, firefighters and the Health Ministry, which runs city hospitals, use different frequencies, hindering effective communication.


Nearly half of the city’s schools require a detailed evaluation to determine how to reinforce them against collapse, Sato said.


A recent media blitz, along with three nationwide quake-tsunami drills this year, helped raise consciousness. The city has spent more than $ 77 million for retention walls and concrete stairs to aid evacuation in hillside neighborhoods, Prado said, but much more is needed.


At the biggest risk, apart from tsunami-vulnerable Callao, are places like Nueva Rinconada.


A treeless moonscape in the southern hills, it is a haven for economic refugees who arrive daily from Peru’s countryside and cobble together precarious homes on lots they scored into steep hillsides with pickaxes.


Engineers who have surveyed Nueva Rinconada call its upper reaches a death trap. Most residents understand this but say they have nowhere else to go.


Water arrives in tanker trucks at $ 1 per 200 liters (52 gallons) but is unsafe to drink unless boiled. There is no sanitation; people dig their own latrines. There are no streetlamps, and visibility is erased at night as Lima’s bone-chilling fog settles into the hills.


Homes of wood, adobe and straw matting rest on piled-rock foundations that engineers say will crumble and rain down on people below in a major quake.


A recently built concrete retaining wall at the valley’s head lies a block beneath the thin-walled wood home of Hilarion Lopez, a 55-year-old janitor and community leader. It might keep his house from sliding downhill, but boulders resting on uphill slopes could shake loose and crush him and his neighbors.


“We’ve made holes and poured concrete around some of the more unstable boulders,” he says, squinting uphill in a strong late morning sun.


He’s not so worried if a quake strikes during daylight.


“But if I get caught at night? How do I see a rock?”


___


Associated Press writer Franklin Briceno contributed to this report.


___


Frank Bajak on Twitter: http://twitter.com/fbajak


Latin America News Headlines – Yahoo! News


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Barnes and Noble Nook HD+ is a Big Screen, Good Value Tablet












Barnes and Noble Nook-HD+


Click here to view this gallery.


[More from Mashable: 7 Stylish iPad Cases With Notepads]












The other night I handed the new Barnes and Noble HD+ to my son to see his reaction to one of the latest 9-inch tablets. He held it, played with the screen and said, “Which one is this?” I told him and he answered, “I can’t tell the difference anymore.” It’s true, with the sudden explosion of 7-, near-8-, 9- and 10-inch-plus tablets, it’s getting a little hard to tell which one is which — especially when many larger tablets look like their tinier siblings.


Barnes and Noble’s large-format (9-inch) HD-screen entry, the HD+, is a quite similar to the 7-inch Nook HD. However, with its somewhat sharper corners and far-reduced black-screen border, it’s also more similar in appearance to larger tablets such as the Amazon Kindle Fire HD 8.9. What sets the Nook apart visually is the trademark nook hole in the lower left-hand corner. It appears to serve no visible purpose, though you could hold the roughly 18-ounce tablet by that corner without too much stress on your hand. It is one of the lightest tablets on the market, although it’s thicker than the Google Nexus 10, Kindle Fire 8.9 and fourth-generation Apple iPad.


[More from Mashable: The 7 Best Tablets for Kids]


Nook HD+’s other distinctive feature is the physical “N” home button on the face of the device. It’s an attribute the Nook HD+ (and 7-inch Nook HD) share with the iPad. As I’ve said before, having that obvious “take me home” button on the front of the device is something I wish every tablet manufacturer would replicate.


Interface


Speaking of replicate, much of what is important and what you need to know about Barnes and Noble’s biggest tablet can be found in my review of the 7-inch Nook HD. The interfaces are exactly the same, so I won’t waste too much space recounting every bit of the Nook HD+ interface, which obscures any trace of Android 4.0, and is exquisitely usable.


The biggest difference between the Nook HD and the HD+ is screen resolution. The HD gets you 1440×900 pixels, while the HD+ offers 1920×1280, which is slightly more than the Kindle Fire HD 8.9’s 1920×1200. The latter two devices are almost the exact same size. By contrast, the competitors’ 7-inch devices are quite different because Amazon includes a front-facing camera, while Barnes and Noble does not include cameras on any of its tablets (if you plan on taking photos or video with your tablet, you can stop reading now). In the case of the Nook HD+, Barnes and Noble uses the space it saves on a camera for, it appears, 80 extra pixels of space. For the record, neither device beats the iPad’s 2048×1536 resolution.


Connectvity


Barnes and Noble also chose to leave out a cellular option from all of its tablets. Amazon, on the other hand, adds it in for the Kindle Fire HD 8.9 LTE. This is not as big of a deal as it seems since the world is filled with high-speed Wi-Fi. Still, if you plan to surf the web on your tablet while sitting on a train without another device to which to tether your HD+, look for products with the mobile broadband option, instead.


When it comes to connectivity, Amazon adds dual-band Wi-Fi to its HD Kindle Fires, while Barnes and Noble’s tablet remains single band. I’ve tested both devices in the most stressful situation -– streaming HD video -– and the difference is negligible.


Using It


Barnes and Noble Nook HD+’s profile-centric interface remains one of the best on the market. There is no learning curve; you simply drag your profile image to the unlock icon, and you have access to the large and uncluttered interface that features a carousel (which like the Kindle is a hodge-podge of disparate icons), your library and some recently used apps. Persistent menu items include the Library, Apps, Web, email and Shop. The screen also includes “your Nook Today,” which, along with the weather, is a place for Barnes and Noble to push shopping options based on your interests.


As you would expect, reading books and magazines is a pleasurable experience, especially on this larger screen. Magazines such as Esquire look great and, yes, Barnes and Noble still employs the animated page turn (though I don’t know for how much longer). Email and Web browsing are solid, and I prefer Barnes and Noble’s web solution to Amazon’s home-grown Silk browser, which crashed too often for my taste.


Social integration is fairly good on the Nook HD+. When I installed the Twitter client, it became one of my options for social sharing. That said, the app looks like it would be more at home on a small-screen smartphone than on the HD+’s 9-inch display. For Facebook, I opted for the web interface, which looks too tiny in portrait mode, but just right in landscape.


Movies and Music


I had no trouble buying, renting and streaming HD-quality movies such Arthur Christmas, and Netflix worked smoothly. Barnes and Noble, however, lacks its own streaming option. If you pay $ 75 a year for Amazon Prime, you get access to a vast library of streaming content. Both devices will let you play HD content on your big-screen TV, though they do it in slightly different ways.


Amazon’s Kindle Fire HD 8.9 comes complete with a mini-HDI-out port, and can accommodate a mini-to-standard HDMI cable (not included), so I could watch the HD content on my big-screen TV. The Nook HD+ lacks an HDMI port, but you can buy a $ 39 adapter (with an HDMI cable), which plugs into the tablet’s 30-pin port, to do the same thing.


I still prefer the Kindle HD platform for music since Amazon’s music services are more deeply integrated into the device and its cloud-based storage offering. On the Nook HD+ you have to start by finding the music service under Apps. If Barnes and Noble is serious about music, it should be on the main menu. Worse yet, if you open the Music app, it offers no instruction on how to fill your music library. You have to add tunes via your computer, by connecting to your PC with the proprietary cable or through the Micro SD slot where you can add more storage or place, say, an entire library of songs.


If you have a Rhapsody Account, you can use it to manage your music needs on the Nook HD+.


I almost never use my large tablet for music (that’s a job for my iPhone or iPod), so I don’t miss the rich music capabilities as much as some others likely would.


Apps and Performance


Like Amazon, Barnes and Noble curates its app library, which generally makes it safe and usable. The key apps, such as Netflix, Twitter, Dropbox, MobiSystems’ OfficeSuite, FlipBoard and Evernote, are all there.


I found some games on there, too, such as the Angry Birds Series and Cut the Rope. On the other hand, Barnes and Noble has very few action games. This may be because, while it’s running the same Texas Instruments Dual core 4470 CPU as the Kindle Fire HD 8.9, it doesn’t offer the same quadcore graphics processing power as Apple’s fourth-generation iPad.


Amazon actually includes the GPU-hungry Asphalt 7 in its app library, but the game does not look particularly good on the Kindle Fire HD 8.9. Obviously, Barnes and Noble chose not to take that risk.


Price


At $ 269 for the 16 GB model (I tested the $ 299 32 GB option), Barnes and Noble’s Nook HD+ is one of the most affordable large-screen tablets on the market — that price even includes the AC adapter. Amazon’s Kindle Fire HD 8.9 costs $ 299, but does not include the charger, and adds subsidizing sleep-screen ads. A 16 GB Wi-Fi-only fourth-generation iPad starts at $ 499.


Obviously, the iPad is more powerful, has a higher resolution and two cameras, while the Kindle, which also includes a camera, offers powerful Dolby stereo speakers (Nook HD+ has ones with decent volume) and unlimited cloud-based storage for your Amazon content. But if those features don’t matter to you, and you’re looking for an attractive, large-screen, light-weight, fun, effective and very affordable tablet from a company that knows a thing or two about good content, you can’t do better than the Nook HD+.


This story originally published on Mashable here.


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Rick Ross cancels shows after gang threats












NEW YORK (TheWrap.com) – Rick Ross has canceled two shows in North Carolina after a gang named Gangster Disciples published a series of YouTube videos threatening the Southern rapper.


Ross, a solo artist, is the founder of Maybach Music Group, a record label that release albums through Warner Bros Records. He was set to perform with fellow Maybach artists Wale, Meek Mill and Machine Gun Kelly in Greensboro on Friday and Charlotte on Saturday. A quick look at the Ticketmaster page evinces that Live Nation has canceled the shows, but a Live Nation spokeswoman did not immediately respond to a request for comment.












Various sects of the Gangster Disciples (GDs), a gang founded on the South Side of Chicago, appear in videos on YouTube threatening Ross and asking him for money. A nearly 10-minute video published recently featuring members of the North Carolina crew is titled “Rick Ross In Trouble with the GD’s North Carolina.”


They claim to have already given Ross a pass “for using our honorable chairman’s name in a disorderly fashion – a dishonest fashion.” That courtesy is over, and they know where Ross will be, mentioning Greensboro and Charlotte. They then say when they catch him in his Maybach his “time is through” and that Ross should know his penalty.


Some of the conflict seems to arise out of a reference to Gangster Disciples’ leader Larry Hoover in Ross’ song “B.M.F (Blowin Money Fast)” – hence the comment about “our honorable chairman.”


Others have said it is not about Hoover and the GDs also appear to be upset that Ross has been acting like more of a gangster than he really is. Affiliated groups, such as ones in Florida and Georgia, have made their displeasure known on YouTube and demanded money.


“We need that cash now, we need that cash – now. We need that cash right now,” one man says in a video from a Florida sect.


“We coming to you as a man William, he adds. “As a man, you supposed to honor your obligations. Therefore you going to do so. Until you do, you going to deal with the mob.”


While both those shows have been canceled, a Sunday show in Nashville, Tenn. remains on schedule.


Music News Headlines – Yahoo! News


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